Kidney Disease Program

Metabolism/Excretion

Metabolized by kidneys, moderately dialyzable 20-50%

Plasma Protein Binding %

Imi: 13-21, Cil: 40

Dose For Normal Renal Function

60-100 mg/kg/day q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

7-13 mg/kg dose q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

7.5-12.5 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

7.5-12.5 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 7.5-12.5 mg/kg dose q24h after dialysis

Supplement For Dialysis [Recommendation Level]: Pd

PD: 7.5-12.5 mg/kg dose q24h, or IP: LD 500 mg/L, maint 200 mg/L

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 7-1 mg/kg dose q8h, [A]