Kidney Disease Program

Metabolism/Excretion

Not removed

Plasma Protein Binding %

75-90

Dose For Normal Renal Function

Oral: 30-50 mg/kg/day q6-8h; IV: 15-50 mg/kg/day q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

10-17 mg/kg dose q8h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 10-17 mg/kg dose q8h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 10-17 mg/kg dose q8h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]