Daptomycin

Plasma Protein Binding %
 
90-95
 
Dose For Normal Renal Function
6 mg/kg dose q24h, no actual pediatric dosing available
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
4 mg/kg dose q24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
4 mg/kg dose q48h
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 4 mg/kg dose q48h after dialysis
Supplement For Dialysis [Recommendation Level]: Pd
PD: 4 mg/kg dose q48h
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 8 mg/kg dose q48h, monitor CPK weekly, [C]