Kidney Disease Program

Metabolism/Excretion

CYP, some renal excretion

Plasma Protein Binding %

65-70

Dose For Normal Renal Function

15 mg/kg/day q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

4 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

4 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 4 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 4 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: Not applicable, [D]