Kidney Disease Program

Metabolism/Excretion

HD 27-58% removed, 10% PD 6 hr dwell

Plasma Protein Binding %

Dose For Normal Renal Function

90-120 mg/kg/day q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

15-20 mg/kg dose q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

7.5-10 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 7.5-10 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 7.5-10 mg/kg dose q12h, or IP: LD 1 g/L, maint 250 mg/L

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [B]