Kidney Disease Program

Metabolism/Excretion

Dialyzable

Plasma Protein Binding %

33-50

Dose For Normal Renal Function

75-150 mg/kg/day q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

25-50 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

25-50 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 25-50 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 25-50 mg/kg dose q24h, PD: LD: 500 mg/L, then 125 mg/L maint

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 25-50 mg/kg q8h, [B]