Kidney Disease Program

Metabolism/Excretion

55% removed by dialysis

Plasma Protein Binding %

35-45

Dose For Normal Renal Function

30 mg/kg/day q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

7.5 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

7.5 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 7.5 mg/kg dose q12h, give 5 mg/kg dose post hemo run

Supplement For Dialysis [Recommendation Level]: Pd

PD: 7.5 mg/kg dose q12h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: Not applicable, [D]