Kidney Disease Program

Metabolism/Excretion

Moderately dialyzable, 20-50%

Plasma Protein Binding %

65-79

Dose For Normal Renal Function

80-160 mg/kg/day q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

20-40 mg/kg dose q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

20-40 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

20-40 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 20-40 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 20-40 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 20-40 mg/kg dose q8h, [B]