Kidney Disease Program

Metabolism/Excretion

<10% removed by dialysis

Plasma Protein Binding %

76-91

Dose For Normal Renal Function

40-80 mg/kg/day q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

20-40 mg/kg dose q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

20-40 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 20-40 mg/kg dose q48h, give on hemodialysis days after dialysis

Supplement For Dialysis [Recommendation Level]: Pd

PD: 20-40 mg/kg dose q48h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 20-40 mg/kg dose q12h, [D]