Kidney Disease Program

Metabolism/Excretion

Hepatic, minimal renal excretion, except normeperidine

Plasma Protein Binding %

60-85

Dose For Normal Renal Function

0.5-2 mg/kg dose q3-4h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: Avoid

Supplement For Dialysis [Recommendation Level]: Pd

PD: Avoid

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, [D]