Kidney Disease Program

Metabolism/Excretion

Partial hepatic

Plasma Protein Binding %

31-50

Dose For Normal Renal Function

100-200 mg/kg/day q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

35-70 mg/kg dose q8-12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

35-70 mg/kg dose q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

35-70 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 35-70 mg/kg dose q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 35-70 mg/kg dose q24h, IP: LD: 500 mg/L, then 125 mg/L maint

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 35-70 mg/kg dose q12h, [B]