Metabolism/Excretion
Excreted in urine as 83% unchanged drug
Dose For Normal Renal Function
Load: 50 µg/kg, then 0.25-75 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
0.33-0.43 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
0.23-0.33 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
0.2 µg/kg/min
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 0.2 µg/kg/min
Supplement For Dialysis [Recommendation Level]: Pd
PD: 0.2 µg/kg/min
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 0.33-0.43 µg/kg/min, titrate to desired effect, [B]
References
Taketomo, Hodding, Kraus. Pediatric Dosage Handbook, 13th edition. Lexi-Comp, 2006.