Metabolism/Excretion
Hepatic metabolism, 10-40% excreted unchanged in urine
Dose For Normal Renal Function
Neonates: 0.75 mg/kg bolus, then 2-5 µg/kg/min; infants and children: 0.75 mg/kg bolus, then 5-10 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
25%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 25%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 25%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, titrate to desired effect, monitor serum concentrations if available, [B]