Metabolism/Excretion
Hepatic metabolism to active cysteine conjugate, 60% excreted unchanged in urine, 30% bile
Dose For Normal Renal Function
1-4 mg/kg/day q12-24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
Not recommended
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not recommended
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not recommended
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: Not recommended, [D]