Kidney Disease Program

Metabolism/Excretion

Liver metabolism, 50% oral, 80% IV dose excreted unchanged in urine

Plasma Protein Binding %

Dose For Normal Renal Function

Oral: 1-6 mg/kg/day q6-12h; IV: 1-2 mg/kgdose q6-12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: Not applicable

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, not hemo or peritoneal dialyzable, [D]