Metabolism/Excretion
Excreted unchanged in urine
Dose For Normal Renal Function
Oral: 20-40 mg/kg/day q6-24h; IV: 2-8 mg/kg/day, up to 20 mg/kg/day, administered q6-24h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
Not recommended
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
Not recommended
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: Not recommended
Supplement For Dialysis [Recommendation Level]: Pd
PD: Not recommended
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, thiazide diuretics not effective when CrCl <30 mL/min/1.73m2, [D]