Fentanyl

Metabolism/Excretion
Hepatic, minimal renal excretion
Plasma Protein Binding %
 
80-85
 
Dose For Normal Renal Function
0.5-2 µg/kg dose or 1-5 µg/kg/hr continuous
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
75%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
75%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
50%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 50%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 50%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 75%, titrate to effect, [B]
References
Hodges UM, Berg S, Naik SK, Bower S, Lloyd-Thomas A, Elliot M. Filtration of fentanyl is not the cause of the elevation of arterial blood pressure associated with post-bypass ultrafiltration in children. J Cardiothorac Vasc Anesth. 1994; 8: 653-7. [PMID: 7880994]