Kidney Disease Program

Metabolism/Excretion

Excreted 50-70% unchanged in urine

Plasma Protein Binding %

20-25

Dose For Normal Renal Function

Consult pediatric reference

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

50% or q36h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

25% or q48h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 25% or q48h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 25% or q48h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, titrate to desired effect, monitor serum concentrations, not dialyzable because of large Vd, [B]