Kidney Disease Program

Metabolism/Excretion

Liver via P450, 90% excreted in urine

Plasma Protein Binding %

92-98

Dose For Normal Renal Function

0.25-0.5 mg/kg dose q6-8h, max 1-2 mg/kg/day

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to desired effect, [D]