Kidney Disease Program

Metabolism/Excretion

Liver via P450, 65% excreted in urine

Plasma Protein Binding %

Dose For Normal Renal Function

0.05-0.2 mg/kg dose, up to 0.8 mg/kg/day, max 20 mg

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to desired effect[D]