Kidney Disease Program

Metabolism/Excretion

Hepatic, 60% metabolites excreted in urine

Plasma Protein Binding %

Dose For Normal Renal Function

0.05-0.17 mg/kg/day, max 10 mg/day

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to desired effect,[D]