Procainamide

Metabolism/Excretion
Acetylation in liver; moderately dialyzable by hemodialysis, not peritoneal dialysis
Plasma Protein Binding %
 
15-20
 
Dose For Normal Renal Function
Oral: 15-50 mg/kg/day q4-6h; IV: 3-6 mg/kg load, 20-80 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
PO: q6-12h, continuous, 100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
PO: q6-12h, continuous, 100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
PO: q8-24h; IV: LD: 12 mg/kg, start at lower end of continuous dosing
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: PO: q8-24h, after dialysis; IV: LD: 12 mg/kg, start at lower end of continuous dosing
Supplement For Dialysis [Recommendation Level]: Pd
PD: PO: q12-24h; IV: LD: 12 mg/kg, start at lower end of continuous dosing
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: PO: q6-12h, continuous, 100%, monitor serum concentrations; procainamide is moderately hemodialyzable, 20-50%; N-acetylprocainamide is not dialyzable; procainamide/N-acetylprocainamide is not peritoneal dialyzable, [B]