Kidney Disease Program

Metabolism/Excretion

90% hepatic

Plasma Protein Binding %

60-80 (AAG)

Dose For Normal Renal Function

0.5-1.5 mg/kg load, 20-50 µg/kg/min

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, monitor serum concentrations, active metabolites can accumulate and cause CNS toxicity, monitor for tremors/seizures, [B]