Kidney Disease Program

Metabolism/Excretion

Hepatic via P450

Plasma Protein Binding %

Dose For Normal Renal Function

Oral: 10-15 mg/kg/day load, 5 mg/kg/day maintenance; IV: 5-10 mg load, 5-15 mg/kg/min

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]