Metabolism/Excretion
Converted to cyanide by erythrocyte and tissue sulfhydryl group interactions; thiocyanate is excreted in urine
Dose For Normal Renal Function
0.3-4 µg/kg/min, max 10 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, titrate to desired effect, monitor thiocyanate serum concentrations because this may accumulate in renal failure, dialyzed by peritoneal and hemodialysis, [D]