Kidney Disease Program

Metabolism/Excretion

Acetylated in liver, 14% excreted unchanged in urine

Plasma Protein Binding %

85-90

Dose For Normal Renal Function

Oral: 0.75-1 mg/kg/day q6-12h, max 200 mg/day; IV: 0.1-0.2 mg/kg dose q6h, max 20 mg dose

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

q8h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

q12-24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: q12-24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: q12-24h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: q8h, [D]