Kidney Disease Program

Metabolism/Excretion

Extensive liver metabolism; undergoes first-pass effect

Plasma Protein Binding %

60-90

Dose For Normal Renal Function

Oral: 0.5-4 mg/kg/day q6-8h, max 16 mg/kg/day; IV: 0.01-0.1 mg/kg dose, up to 1 mg for infants, 3 mg for children

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, not dialyzable, [D]