Kidney Disease Program

Metabolism/Excretion

Extensive liver metabolism

Plasma Protein Binding %

12 (albumin)

Dose For Normal Renal Function

1-2 mg/kg/day q12-24h (limited studies)

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%, dose after dialysis

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to desired effect,[D]