Kidney Disease Program

Metabolism/Excretion

Minimal renal excretion

Plasma Protein Binding %

Dose For Normal Renal Function

Oral: 3-20 mg/kg/day q12h; IV: 0.2-0.5 mg/kg dose intermittent or 0.4-3 mg/kg/hr

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to desired effect,[D]