Kidney Disease Program

Metabolism/Excretion

69% excreted unchanged in urine

Plasma Protein Binding %

Dose For Normal Renal Function

0.5 mg/kg load, 50-300 µg/kg/min (doses up to 1000 µg/kg/min reported)

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to desired effect, [D]