Metabolism/Excretion
Liver metabolism to active metabolites, glucuronide conjugation before excretion; excreted in urine as oxazepam, desmethyldiazepam, and N-methyloxazepam
Plasma Protein Binding %
Neonates: 84-86, adults: 98
Dose For Normal Renal Function
Oral: 0.12-0.8 mg/kg/day q6-8h; IV: 0.04-0.3 mg/kg dose q6-8h
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, titrate to effect, [D]