Metabolism/Excretion
Liver via hydroxylation and oxidation; only 1% eliminated renally
Dose For Normal Renal Function
1-2 mg/kg dose q2-6h, or 1-3 mg/kg/hr (for pentobarbital coma, higher doses may be warranted)
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, titrate to effect, injection solution contains 10% alcohol and 40% propylene glycol, monitor for s/s of toxicity, not dialyzable, [D]