Kidney Disease Program

Metabolism/Excretion

Extensive liver, renal excretion 71%, biliary/fecal 18%

Plasma Protein Binding %

Dose For Normal Renal Function

0.5-1 mg/kg/day, data limited

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]