Kidney Disease Program

Metabolism/Excretion

Excreted unchanged in urine

Plasma Protein Binding %

Dose For Normal Renal Function

0.1-0.2 mg/kg dose q8h or q6h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

50%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

25%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 25%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 25%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, [B]

References

Bateman DN. Clinical pharmacokinetics of metoclopramide. Clin Pharmacokinet. 1983; 8: 523-9. [PMID: 6360466]