Kidney Disease Program

Metabolism/Excretion

Liver to inactive metabolites

Plasma Protein Binding %

Dose For Normal Renal Function

0.5-1.6 mg/kg/day: <10 kg = 7.5 mg q24h; 10-30 kg = 15 mg q24h or q12h; >30 kg = 30 mg q24h or q12h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]