Kidney Disease Program

Metabolism/Excretion

Excreted in feces and bile (50%), 25% excreted in urine

Plasma Protein Binding %

60-80

Dose For Normal Renal Function

0.1 mg/kg dose q1-2h; continuous infusion: 0.5-0.12 mg/kg/hr

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to effect, [D]