Metabolism/Excretion
Liver via glucuronidation and sulfate conjugation, excreted 90% in urine as metabolites
Dose For Normal Renal Function
Consult pediatric reference; doses vary upon indication
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, titrate to effect, in the US propofol has a black box for use in children, monitor for s/s of propofol infusion syndrome
References
Morcos WE, Payne JP. The induction of anaesthesia with propofol (‘ Diprivan’ ) compared in normal and renal failure patients. Postgrad Med J. 1985; 61 Suppl 3: 62-3. [PMID: 3877297]