Kidney Disease Program

Metabolism/Excretion

30-40% metabolized by liver, 60% excreted in urine, 40% bile

Plasma Protein Binding %

Dose For Normal Renal Function

0.1-0.2 mg/kg dose q2-4hor 0.5-1 µg/kg/min

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

50%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

50%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

Avoid

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: Avoid

Supplement For Dialysis [Recommendation Level]: Pd

PD: Avoid

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 50%, titrate to effect, [D]