Kidney Disease Program

Metabolism/Excretion

Hepatic, excreted in urine

Plasma Protein Binding %

50-60

Dose For Normal Renal Function

Oral: 0.1 mg/kg dose q12h-24h; IV: 5-10 µg/kg dose q8-24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, [D]