Kidney Disease Program

Metabolism/Excretion

Liver via N-dealkylation, glucuronide conjugation

Plasma Protein Binding %

Dose For Normal Renal Function

Bolus: 1-2 mg/kg; continuous infusion: 5-20 µg/kg/min

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, titrate to effect, [B]

References

Reich DL, Silvay G. Ketamine: an update on the first twenty-five years of clinical experience. Can J Anaesth. 1989; 36: 186-97. [PMID: 2650898]