Metabolism/Excretion
Hofmann elimination, ester hydrolysis
Dose For Normal Renal Function
Bolus: 0.1 mg/kg; continuous infusion: 0.5-4 µg/kg/min
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, titrate to effect, [D]