Metabolism/Excretion
Liver metabolism, exhibits MM kinetics after single dosing, then P450 and induces itself after multiple dosing
Dose For Normal Renal Function
No hemodialysis: 15 mg/kg load, then 10 g/kg q12h until ethylene glycol or methanol levels <20 mg/dL. Hemodialysis: During HDadminister q4h or as a continuous infusion of 1-1.5 mg/kg/hr
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, [D]