Metabolism/Excretion
Liver (CYP 450) and intestine, eliminated primarily by bile
Dose For Normal Renal Function
PO: 0.15-0.4 mg/kg/day divided q12h; IV continuous: 0.03-0.15 mg/kg/day divided by 24 hours
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
See note
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
See note
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
See note
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: See note
Supplement For Dialysis [Recommendation Level]: Pd
PD: See note
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: See note, [D]
Toxicity Notes
Patients with renal and/or hepatic impairment should receive the lowest dose in the dosage range and monitor serum concentrations.