Sirolimus

Metabolism/Excretion
Liver (CYP 450) and intestine, eliminated by feces (91%)
Plasma Protein Binding %
 
92
 
Dose For Normal Renal Function
>13 yo and <40 kg: 3 mg/m2 first day, maint 1 mg/m2/day
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
100%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
100%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 100%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 100%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 100%, monitor serum concen- trations when possible, [D]