Kidney Disease Program

Metabolism/Excretion

95% excreted in urine

Plasma Protein Binding %

25-30

Dose For Normal Renal Function

0.1-0.5 mg/kg dose q6-8h, max 6 mg/kg/day

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50%

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75%, [D]