Kidney Disease Program

Metabolism/Excretion

Extensive hepatic metabolism by xanthine oxidase to 6-MP

Plasma Protein Binding %

Dose For Normal Renal Function

2-5 mg/kg/day q24h, then 1-3 mg/kg/day q24h depending upon condition being treated

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

75% q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

75% q24h

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

50% q24h

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 50% q24h

Supplement For Dialysis [Recommendation Level]: Pd

PD: 50% q24h

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 75% q24h, [D]