Metabolism/Excretion
~75% drug metabolized to active metabolites, mostly oxypurinol
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
30%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 30%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 30%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50%, [D]
References
Taketomo, Hodding, Kraus. Pediatric Dosage Handbook, 13th edition. Lexi-Comp, 2006.