Kidney Disease Program

Metabolism/Excretion

Half-life prolonged in renal failure, not dialyzable

Plasma Protein Binding %

20-40

Dose For Normal Renal Function

5-10 µg/kg/day q8-12h, max 0.9 mg/day

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: 100%, dose after dialysis

Supplement For Dialysis [Recommendation Level]: Pd

PD: 100%

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]