Kidney Disease Program

Metabolism/Excretion

Extensive liver metabolism by methylation of thioguanine to 2-amino methylthioguanine, metabolites excreted in urine ~40%

Plasma Protein Binding %

Unknown

Dose For Normal Renal Function

Refer to individual protocols

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29

100%

Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10

100%

Supplement For Dialysis [Recommendation Level]: Ihd

IHD: No data

Supplement For Dialysis [Recommendation Level]: Pd

PD: No data

Supplement For Dialysis [Recommendation Level]: Crrt

CRRT: 100%, [D]