Metabolism/Excretion
Liver metabolism to 7-hydroxymethotrexate; primarily excreted in the urine (90%) via glomerular filtration and active secretion by renal tubule
Dose For Normal Renal Function
Refer to individual protocols
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 30-50
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 10-29
50%
Adjustment For Renal Function Gfr, Ml/Min/1.73M2 <10
30%
Supplement For Dialysis [Recommendation Level]: Ihd
IHD: 30%
Supplement For Dialysis [Recommendation Level]: Pd
PD: 30%
Supplement For Dialysis [Recommendation Level]: Crrt
CRRT: 50%, monitor serum concentrations, the Pediatric Dosage Handbook recommends decreasing dose for CrCl 61-80 by 25% and CrCl 51-60 by 33%, [A]